Targeting Chemotherapy-Induced Premature Ovarian Failure: a Novel Therapeutic Strategy Using Er+Pcmsc Secretome in Ovarian Niche Regulation and Clinical Research

Project: A - Government Institution › b - National Science and Technology Council

Project Details

Description

目前臨床上尚缺乏針對化療後之卵巢早衰症 (Chemotherapy-induced premature ovarian failure, POF) 有效的治療措施。本計畫將發展一呼應卵巢微環境，以表現雌激素受體之胎盤間質幹細胞分泌體 (ER+pcMSC secretome)，提出化療後之卵巢早衰症之治療策略，聚焦調控卵巢具雌激素微環境之體外體內前臨床研究，並進一步提供ER+pcMSC secretome克服化療後之卵巢早衰症治療的科學依據，與臨床研究驗證。
StatusFinished
Effective start/end date8/1/23 → 7/31/24

Keywords

  • Chemotherapy-induced premature ovarian failure
  • ER+ placenta MSC
  • Secretome
  • Estrogen
  • Granulosa cell
  • Clinical research