Survival and Invasiveness of Prostate Cancer Post Modulation of Mitochondrial Dynamics and Metabolism Modulated by Pgc1α/Sirt3/Etc Complexes-Assessment of the Strategy Utilizing Sirt3 Regulator to Attenuate Chemoresistance

Project: A - Government Institutionb - National Science and Technology Council

Project Details

Description

攝護腺癌晚期去勢抗性,雄性素受體活化,調控粒線體能量,加重抗藥性及轉移. PGC1α調控粒線體生合成,協調細胞核與粒線體,SIRT3乃PGC1α下游,直接結合電子傳遞鏈,然迄今無PGC1α/SIRT3/電子傳遞鏈研究粒線體能量與攝護腺癌進展.前實驗顯示抗雄性素降低腎粒線體生物能,減少電子傳遞鏈複合體I及SIRT3,增加自噬.考慮粒線體代謝及致癌訊息同時影響抗藥性,結合探討有益突破治療. 厚朴酚抑制攝護腺癌,活化SIRT3,然無粒線體呼吸鏈及動態調控探討. 粒線體是Docetaxel標的,本計畫擬評估厚朴酚經AR/PGC1α/SIRT3調控呼吸鏈及粒線體動態,緩解化學抗性. 預期臨床應用價值極高
StatusFinished
Effective start/end date8/1/217/31/22

Keywords

  • Prostate Cancer
  • Sirtuin 3 NAD+- Dependent Protein Deacetylase
  • Mitochondria Dynamics & Metabolic Reprogramming
  • Electron Transport Chain Complexes
  • Chemoresistance