Studying on the Molecular Mechanism in Which Grk6 Promotes the Metastatic Progression of Triple-Negative Breast Cancer via Regulating Pi3k/Akt/Mtor Activity and Autophagy Formation and Its Applications in Precision Oncology( III )

Project: A - Government Institution › b - National Science and Technology Council

Project Details

Description

癌症登計資料顯示，乳癌是台灣婦女癌症的首位，每年逾萬新發乳癌個案、超過2000名婦女死於乳癌, 此現象對國家,人文, 社會, 經濟皆有很大的衝擊,因此提昇乳癌診治品質己是刻不容緩的重要公共衛生議題. 本計畫的結果，除了能瞭解GRK6促進TNBC細胞轉移的分子機制，也能提供GRK6當作臨床使用mTOR抑制劑(如: Temsirolimus and Everolimus)治療轉移型TNBC效果之生物標記的依據，達到癌症精準醫學的精隨,同時提昇學術發展的品質.
StatusFinished
Effective start/end date8/1/23 → 7/31/24

Keywords

  • Triple negative breast cancer
  • chemoresistance
  • metastasis
  • GRK6
  • PI3K inhibitors