Study the Role of the Endoplasmic Reticulum Stress Related Proteins, Glycoprotein 96(Gp96), in Liver Cancer Progression and Metastasis and the Clinically Therapeutic Implication

Liver cancer is the most important and leading causes of cancer death for people in Taiwan. Several studies showed that the endoplasmic reticulum stress related proteins glycoprotein 96 (GP96) was correlated the cancer progression and therapeutic response in deferent cancers. However, the role of GP96 in progression and therapeutic response in HCC cancer is still unclear. In order to understand the role of GP96 in HCC, we tried to knockdown the expression of GP96 in HCC cells line. To verify the proliferatory and migratory ability, we found that silenced of GP96 cause the reduction the proliferation activity and migratory ability in Hep J5 cells. Those preliminary results demonstrated that GP96 may play important role in HCC progression and metastasis. Here, we planned to further dissect the role of GP96 on HCC. In this study, we intended to dissect the role of GP96 in HCC progression and metastasis. Further, we planned to dissect the role of GP96 in chemo-resistant and irradiated resistant of HC. We believe that ER-stress related protein may become an important target in monitoring the HCC diagnostic or therapeutic efficacy.