Study the Mechanism of Chemokine-Ccl5 and Its Receptors in Neurogenesis and Differentiation.(1/3)

Project: A - Government Institutionb - National Science and Technology Council

Project Details

Description

本研究探討免疫趨化物CCL5與其接受器CCR5, GPR75在神經發育分化的過程中的角色影響。初步研究發現CCL5可促進一般小鼠海馬迴成年神經再生(Adult hippocampus neurogenesis, AHN),本研究想進一步探討CCL5對神經分化與再生的基因調控以及影響。進而了解在是否會影響神經發育與成年後的神經再生,以利日後在神經退化的應用。
StatusFinished
Effective start/end date8/1/237/31/24

Keywords

  • CCL5
  • CCR5
  • GPR75
  • neurogenesis and differentiation
  • inducible pluripotency stem cells (iPSCs)