Study on the cancer and non-cancer, including cardovascular diseases, risks in cohort population with prolonged low-dose radiation exposure

Low dose radiation exposure has been shown to induce higher risks of cancers and non-cancerous disease on human populations. There needs long-term follow-up to be able to identify potential health risks. Several international cohort study have been base on their researches on mortality data, which is more accessible for analysis. However, modern medical services might have changed the mortality of some cancers; e.g. thyroid can breast cancers, and realize it is important to analyze morbidity as better indicators of incidences. Therefore, issues including survival time, which were the cancers mortalities data compatible with incidences, the potential bias if mortalities were available, et al will be essential important to address. Since 1982 to 1992 and following, a unique cohort population in Taiwan was established which included individuals and families stayed by residence, schooling, or occupations, in buildings using Co-60 contaminated building (RCB) in several cities in Taiwan. The PI (Pr. Chang) and several other scientists in Taiwan and international scholars have followed up this cohort population and together published more than 40 scientific manuscripts internationally. Their world pave the basis for this project research, including the health effects of this cohort on risk of cancers and non-cancer tumors, the risks of cardiovascular disorders, which will be based on Excess relative risk (ERR) and Excess absolute risk (EAR). These will be compared with those in the general public in Taiwan. It also aims to identify the best model of risk analysis on this cohort population, with specific cumulative exposure, as well as the modifiers and associated factors involved. Part of the efforts will focus on refinement of exposure assessment in some subgroup of the cohort, organ-specific exposure assessment, to develop organ-specific exposure-based risk assessment. Survival analysis will be conducted simultaneously, and it association with health intervention and medical follow-ups. There will be relayed to other international cohort studies to strengthen the risk analysis on low dose radiation exposure on human populations