Study Differentiation of Oligodendrocyte Progenitor Cells and Overcome Intrinsic Treatment Resistance by Dissecting Intratumoural Heterogeneity in Malignant Glioma

Project: A - Government Institutionb - National Science and Technology Council

Project Details

Description

本研究主旨在於藉由單細胞測序技術研究新診斷之膠質母細胞瘤檢體內,可能在治療後殘存且具治療抵抗性之腫瘤幹細胞,並研究其生物特性。並進一步找出其可能治療之機轉,在腫瘤發現時就可以予以評估後續治療反應及若其產生腫瘤復發及治療抵抗性後之應對策略。克服目前無法提升患者預後之困境。
StatusFinished
Effective start/end date8/1/237/31/24

Keywords

  • glioblastoma
  • single cell sequencing
  • oligodendrocyte progenitor cell
  • treatment resistance
  • mesenchymal transition