Strategy for Treatment of Osimertinib-Resistant Lung Adenocarcinoma by Jnk Activation

  • Yao, Chih-Jung (PI)

Project: A - Government Institutionb - National Science and Technology Council

Project Details

Description

探討藉由現有之藥物與食品成分,活化第三代標靶藥物Osimertinib抗藥性肺腺癌之JNK路徑,以促使其EGF受體經由自噬 (autophagy) 作用而分解的治療策略。面對不斷產生的EGF受體抗藥性突變,若能藉由活化其JNK路徑使其分解失效,可省去不斷地開發更新一代的標靶藥物的龐大資源。期能為標靶藥物治療失效之肺腺癌研發另一治療策略。
StatusFinished
Effective start/end date8/1/217/31/22

Keywords

  • lung adenocarcinoma
  • resistance to targeted drugs
  • autophagy
  • JNK