Severe Prematurity and Early-Life Adversity Exposures in Periviable Neonates Alters Immature Brain Connectivity Development and Impairs Neurodevelopmental Performance Outcomes in Association with Exacerbated Disruptions of the Gut Microbiota-Immune System( I )

Project: A - Government Institution › b - National Science and Technology Council

Project Details

Description

在重症醫療的進步以及孕齡 (GA) 閾值的降低下，生存邊緣早產兒（孕齡22–25週）、極度早產兒（EP，孕齡26–27週）及非常早產兒（VP，孕齡28–30週）的存活率顯著提高。儘管存活率提高，生存邊緣早產兒仍面臨高比例的生長遲滯及神經發展障礙(NDI)。保護其發育中的大腦免於長期神經發展後遺症已成為重要的臨床優先事項。辨識生存邊緣早產兒在足月等效年齡(TEA)時，特有的大腦異常發展模式及其與發育軌跡的關聯，將有助於制定早期介入措施，以降低這一脆弱群體中神經發展障礙 (NDI) 的高發生率。。
StatusActive
Effective start/end date8/1/25 → 7/31/26

Keywords

  • Severity of prematurity
  • Periviable infant
  • Risk exposure burden
  • Brain structural connectivity
  • Brain functional connectivity
  • MRI
  • growth
  • neurodevelopmental impairment
  • gut microbiota succession
  • microbiota-immune system