Serum Translocator Protein (Tspo) as Biomarker of Brain Damage in Cognitive Ability and the Related Association with Neuro-Inflammation.

Project: A - Government Institutionb - National Science and Technology Council

Project Details

Description

系統性慢性發炎反應及神經發炎反應被推測與認知功能損傷有關。但發炎指標如CRP雖被研究者關注,但不具中樞神經系統的組織專一性。本研究團隊已證實轉位蛋白在腦梗塞及腦出血時能反映急性神經元損傷且能預測臨床預後。在族群系統性發炎指標基礎下,瞭解新式神經元發炎指標TSPO在台灣地區篩選早期認知功能損傷的能力,並了解其潛在機制,有助於在社區中及臨床早期時,篩選輕微認知功能損傷病人。
StatusFinished
Effective start/end date8/1/217/31/22

Keywords

  • inflammation
  • neuroinflammatory
  • impairment cognitive decline
  • dementia
  • MMSE
  • MoCa
  • Mendelian randomization