Serpin B III Implicated in Il-6 Trans Signaling Induced Airway Epithelial Dysfunction in Asthmatics

Project: A - Government Institution › b - National Science and Technology Council

Project Details

Description

部分氣喘患者會持續出現氣道過度敏感、氣道纖維化、杯狀細胞增生、氣道發炎，現認為由氣道IL-6 trans signaling (IL-6TS)所引起。SERPIN B3/4 在氣喘有高度的表現。本計畫將探討IL-6TS刺激氣道上皮細胞其調控生理訊息變化，將以塵蟎過敏原刺激小鼠，以soluble gp130, anti-TLR2,4或抗內毒素抗體抑制之，檢視是否內毒素會經由Toll like receptor (TLR)引發IL-6TS反應。本計畫將揭示SERPIN B3/4在氣道上皮細胞IL-6TS反應的重要角色，拮抗SERPIN B3/4可以改善氣道上皮細胞功能失調，增進氣喘的控制。
StatusFinished
Effective start/end date8/1/23 → 7/31/24

Keywords

  • SERPIN B3/4
  • IL-6
  • IL-6 trans signaling
  • airway epithelium
  • asthma
  • airway remodeling
  • airway epithelial permeability

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