Roles of the Hdacs/Sp1-Mediated Microrna-106b~25 Axis in Drug Resistance of Glioblastomas( III )

Project: A - Government Institutionb - National Science and Technology Council

Project Details

Description

經由本計畫的執行,將能闡明HDAC1, 2, 6/Sp1-miR-106b~25軸在腦瘤發生抗藥性過程中所扮演的角色,同時亦能以此軸為標的研發治療腦瘤的新穎藥物,並能開發循環性 miRNAs做為診斷患者預後的有效生物標誌。本計畫成果將有助於建立創新性策略,用以治療GBM患者;並能提昇國人健康品質,節省國家健保資源。
StatusFinished
Effective start/end date8/1/217/31/22

Keywords

  • GBM
  • Drug resistance
  • HDAC/Sp1
  • miR106b-93-25 cluster gene
  • Drug candidates
  • Biomarker signatures