Chronic complications are the major cause if death in diabetes mellitus and kidney disease is one of the most common complications. Strict control of blood sugar and blood pressure can retard the progression of diabetic nephropathy (DN). Many reports demonstrated advantages of soy protein for antihypertension, protection against renal dysfunction, and improvement in insulin resistance. The aim of the study is to clarify the bioactive components of soy protein in the treatment of DN and the underlying mechanisms. In the first part of the study, we will use different amount of soy protein in substitution of dietary protein in spontaneously hypertensive rats (SHRs) with streptozotosin (STZ)-induced diabetes to investigate their effects. In the second part of the study, we will use -conglycinin and isofalvones equivalent to the effective dose which will be found in the first part to investigate their effects on renal function, blood pressure and blood sugar control. In the third part of the study, we will use different fractions of pepsin-pancreatindigested -conglycinin to clarify their effects on proteinuria and expression of podocyte-related proteins such as nephrin and zonula occludens-1. We expect that -conglycinin and soy isoflavones may retard the progression of diabetic nephropathy and may be suggested to diet modification in high risk groups or development of related food products.
|Effective start/end date
|8/1/12 → 7/31/13
- renal function
- soy protein
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