Phosphorylation of Dicer Targets on Metabolic Vulnerability and Gemcitabine Resistance in Translational Pancreatic Cancer Research

Project: A - Government Institutionb - National Science and Technology Council

Project Details

Description

就目前文獻資料及我們所知,尚未有相關研究磷酸化Dicer如何影響吉西他濱抗藥性及麩醯胺酸代謝依賴。成功執行此計畫,將了解磷酸化Dicer促進胰臟癌麩醯胺酸代謝依賴,利用其麩醯胺酸代謝上的弱點,合併代謝藥物治療可望提升吉西他濱的藥效。此計畫對提升癌症代謝藥物治療領域將有重要的影響,並可發展胰臟癌精準診斷和提升吉西他濱治療的效果。
StatusFinished
Effective start/end date8/1/227/31/23

Keywords

  • Dicer phosphorylation
  • glutamine
  • metabolic dependency/vulnerability
  • gemcitabine
  • pancreatic cancer