Multimodality Brain Mapping for Epilepsy Surgery：Analytic High Frequency Oscillations Features of Multichannel Intracranial Eeg

Epilepsy is a common neurological disorder. Approximate 1% of population needs to receive antiepileptic treatment for recurrence of epileptic seizures. About 30% seizures are not controlled adequately with antiepileptic drugs. Resective epilepsy surgery remains as effective therapeutic option. A candidate for epilepsy surgery therapy must have not attained acceptable seizure control with optimal trials of antiepileptic medication and must have a reasonable change of benefiting from surgery. The outcome of the resective surgery relies on successful resection of epileptogenic zone in where responsible for the generation of focal seizures. Accurate localization of the epileptogenic zone is based on comprehensive presurgical assessments that include neurophysiology and neuroimaging. However, many patients with drug-resistant epilepsy are not excellent candidates for surgical resection of the epileptogenic zone. The project is aimed to develop multimodality brain mapping for epilepsy surgery by analyzing high frequency oscillations features of multichannel intracranial EEG. The multimodality neurophysiological and neuroimaging biomarkers of human are established for the basic and clinical researches to explore the physiological mechanisms of generation and termination of epileptic seizures. The subject has been looking forward to developing more efficient diagnosis protocols and more individualized treatment.