Molecular and Immunopathogenesis of Recombinant Toxocara Antimicrobial Peptides in Wound Healing on Skin Lesion Infected by Opportunistic Staphylococcus Aureus and Therapeutic Effects on Systemic Sepsis Caused by Mdrsa in Mice (1/3)

Project: A - Government Institution › b - National Science and Technology Council

Project Details

Description

伺機性金黃色葡萄球菌(Staphylococcus aureus)與多重抗藥性金黃色葡萄球菌(MDRSA)，危害人類健康甚鉅。因天然抗微生物胜肽(AMPs)量少，化學合成AMPs費用昂貴，藉基因轉殖技術，大量表達抗微生物重組胜肽(rAMPs)是最具前瞻性的方法。若本實驗得以完成，No.9、No.10與No.11之犬蛔蟲抗微生物重組胜肽(rTcAMPs)將有潛力成為替代抗藥性菌抗生素與加速傷口癒合雙重功能的候選臨床用藥。
StatusFinished
Effective start/end date8/1/22 → 7/31/23

Keywords

  • Staphylococcus aureus
  • multidrug resistant S. aureus (MDRSA)
  • E. coli BL21 expressing system
  • recombinant Toxocara antimicrobial peptides
  • keratinocytes
  • fibroblasts
  • endothelial cells
  • cell proliferation and migration
  • mice
  • skin wound healing
  • sepsis
  • molecular and immunopathogenesis

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