Mechanisms of Resveratrol on Advanced Glycation End Products and Methylglyoxal-Induced Renal Damage

The aim of the study is to investigate the effects of resveratrol on advanced glycation end product and methylglyoxal-induced renal and endothelial injury. In the first part of the study, we will investigate the influence of receptor for advanced glycation end product on inflammasome pathway and we will also evaluate the effects of different advanced glycation end products on renal function in mice. In the second part, we will clarify the inhibition of inflammasome activation via blocking advanced glycation end product-receptor interaction through decreasing oxidative stress. In the third part, we will further investigate the beneficial effects of dietary resveratrol supplementation on methylglyoxal-induced renal injury via inhibition of inflammasome activation. We expect resveratrol may show its protective effects on advanced glycation end product and methylglyoxal-induced renal injury by regulating the inflammasome related inflammatory responses.