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Investigation of the Pathological Role of Serine/Threonine Kinase 33 (Stk33) in Thrombin-Induced Chemokine Il-8/Cxcl8 Expression and Airway Inflammation in Severe Asthma

Project: A - Government Institution › b - National Science and Technology Council

Project Details

Description

嚴重氣喘是難以治癒的慢性呼吸道發炎疾病，本計畫預期找出嚴重氣喘中thrombin誘導肺部上皮細胞IL-8/CXCL8釋放，其STK33病理角色以及轉譯醫學的研究。藉由這次的研究成果，可用於嚴重氣喘呼吸道發炎及對類固醇治療反應不佳的病人，開發可能改善的藥物，並將研究成果發表在國際學術期刊中。
StatusFinished
Effective start/end date8/1/23 → 7/31/24

Keywords

  • Severe asthma
  • Airway inflammation
  • Serine/threonine kinase 33 (STK33)
  • Thrombin
  • IL- 8/CXCL8)
  • Myc-associated zinc finger protein (MAZ)
  • Ovalbumin (OVA)