Investigation of the Effects of Ccl5 Mediated Neuronal Energy Metabolism on Hippocampal Neurogenesis and Memory Formation under Normal and Alzehemier’S Disease Conditions

Project: A - Government Institutionb - National Science and Technology Council

Project Details

Description

本計畫希望能藉由CCL5改善神經元有氧呼吸,探討CCL5對於海馬迴成年神經再生的活化與基因的調控,希望能改善阿茲海默症的神經元活性與記憶退化狀況。日後提供臨床治療的新方向。另外,在基礎研究方面,本研究會對於免疫趨化物CCL5在神經幹細胞分化與再生有突破性的了解,尤其是在促進成年後的神經再生機轉。
StatusFinished
Effective start/end date8/1/227/31/23

Keywords

  • CCL5
  • Alzheimer's disease
  • adult hippocampal neurogenesis
  • inducible pluripotency stem cells (iPSCs) neurogenesis
  • aerobic glucose metabolism