Investigation into the Impact of Prdx6-Induced Non-Canonical Cell Death on Immune Resistance in Upper Tract Urothelial Carcinoma

Project: A - Government Institutionb - National Science and Technology Council

Project Details

Description

本計劃旨在提升免疫檢查點抑制劑(Immune checkpoint inhibitors, ICIs)治療轉移性上尿道尿皮腺癌(UTUC)的療效。透過增進公眾對ICIs治療的認識,計劃將提升UTUC患者的生活質量和社會支持。經濟上,改善治療策略將降低醫療成本,刺激生物醫學產業發展。學術上,計劃將深化對UTUC免疫抗性機制的了解,尤其是PRDX6的作用,為癌症研究提供新視角。臨床上,探索針對PRDX6的治療策略有望提升ICIs的療效,提高患者生存率。總體而言,本計劃將對患者福祉及學術創新產生深遠影響,提升UTUC治療水平,對社會產生正面影響。
StatusActive
Effective start/end date8/1/247/31/25

Keywords

  • upper tract urothelial carcinoma (UTUC)
  • immune checkpoint inhibitors (ICIs)
  • PRDX6
  • immunoresistance
  • ferroptosis