Investigating the Role of Tumor-Derived Exosomal Icam-1 in Regulating Metastasis and Therapy of Kras-Mutated Colorectal Cancer under Hyperlipidemia

Project: A - Government Institution › b - National Science and Technology Council

Project Details

Description

KRAS基因突變性大腸直腸癌對於EGFR標靶藥物反應皆不佳，並且具有易轉移、抗藥性等不良預後結果，我們認為大腸直腸癌病人若同時具有高血脂，是造成上述治療效益低下的主因。本研究所探討的IL-8與ICAM-1可能成為此診斷標誌，並且透過合用化療藥物、抗氧化藥物與阻斷IL-8/ICAM-1的活性可增加高血脂環境下轉移性大腸癌治療效益。
StatusActive
Effective start/end date2/1/25 → 1/31/26

Keywords

  • KRAS mutation
  • hyperlipidemia
  • ICAM-1
  • IL-8
  • CRC metastasis