Investigating the Interactive Effect between Hmgb1 and Rage Pro-Inflammatory Axis in Glioblastoma and the Potential as a Novel Targeted Therapy

Project: A - Government Institutionb - National Science and Technology Council

Project Details

Description

若成功執行此計畫,將使我們對癌細胞內HMGB1和RAGE如何參與影響惡性神經膠質瘤進展的分子機制,以及這些調控 HMGB1和RAGE 表現的分子有更多的瞭解。本計畫中研究HMGB1和RAGE促發炎因子之交互作用對惡性神經膠質瘤惡化、轉移與抗藥性的影響及其機制,在未來有潛力可發展為新的診斷方式及治療策略。
StatusActive
Effective start/end date8/1/247/31/25

Keywords

  • RAGE/HMGB1 pro-inflammatory axis
  • RAGE gene
  • Glioblastoma therapy