Investigating Influences of Neuronal State in Local and Large-Scale Cortical Networks during Rest and Task on Subsequent Neuronal Activity and Behavioral Performance: a Multi-Model Approach

Project: A - Government Institutionb - National Science and Technology Council

Project Details


Growing studies suggest that moment-to-moment neuronal state might be a critical factor regulates forthcoming neural activities and corresponding behavioral responses. The dynamic neuronal state of each brain region is not only controlled by local neuron assemblies, but also affected by distal brain regions via coherently oscillating to communicate each other. However, the measurement of neuronal state is diverse across different neuroimaging techniques without coherent findings. Multi-neuroimaging research approach is needed to investigate the neuronal state in a comprehensive way. Furthermore, two separate neural networks for default mode and executive were found, indicating large-scale cortical networks may contribute differently in different contexts. Therefore, in this proposal, we propose a series of experiments to examine the neuronal state under three different contexts: task free, tasks-induced, and artificial boost via non-invasive brain stimulation, to examine how the dynamic neuronal activities, including local and distal communications, alternate under different contexts. Meanwhile, the underlying metabolism varies with synchronous activity on cortico-cortical interactions across these three different contexts will be examined as well to provide groundwork for predicting on forthcoming neuronal activities.
Effective start/end date8/1/177/31/18


  • neuronal state
  • resting state
  • conflict adaptation
  • electroencephalography
  • magnetic resonance spectroscopy
  • noninvasive brain stimulation
  • transcranial magnetic stimulation


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