Identification Pklr Metabolic Pathways and Therapeutic Roles in Promoting Neuroendocrine Differentiation of Prostate Cancer

Project: A - Government Institution › b - National Science and Technology Council

Project Details

Description

本計畫研究PKLR在前列腺腫瘤代謝途徑和神經內分泌分化的關鍵功能，了解PKLR基因的活化影響前列腺癌細胞屬性可塑性和粒線體失調的分子機制。本研究探討PKLR在前列腺癌雄激素剝奪療法後，影響粒線體功能和神經內分泌分化的致癌作用機制。PKLR活化可能會刺激CHRM4-AKT-MYCN訊號通路，通過標靶PKLR和CHRM4可以提供對前列腺癌轉移復發患者有效的預測及新穎治療策略。
StatusFinished
Effective start/end date8/1/21 → 7/31/22

Keywords

  • Androgen deprivation therapy (ADT)
  • Lineage plasticity
  • Neuroendocrine differentiation
  • Metabolic pathway
  • Pyruvate kinase liver and red blood cell (PKLR)
  • Cholinergic receptor muscarinic 4 (CHRM4)

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