Exploiting the Role of Acsl1/Fasn Signaling in Lipid Metabolic Reprogramming as a Novel Therapeutic Strategy for Patients with Chemo-/Immuno-Therapy-Resistant and Metastatic Urothelial Carcinoma

Project: A - Government Institution › b - National Science and Technology Council

Project Details

Description

本計畫的研究成果將有助於增加我們對癌症代謝、TGFβ/β-catenin signaling和患者免疫狀況之間調控機制的理解，闡明靶向ACSL1/FASN/TGFβ/β-catenin signaling axis對治療局部晚期/ 無法切除或轉移泌尿道上皮癌的可行性，並提供臨床試驗之良好基礎。
StatusFinished
Effective start/end date8/1/21 → 7/31/22

Keywords

  • Urothelial carcinoma
  • ACSL1
  • FASN
  • TGFβ
  • β-catenin
  • advanced disease
  • metastasis
  • T cells
  • immunosurveillance
  • immunotherapy
  • therapy-resistance
  • lipid metabolism
  • metabolic reprogramming

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