Exploiting Acridine Scaffold to Develop Novel Anticancer Agents Based on a Dual Target Strategy

Pharmacology, Toxicology and Pharmaceutical Science

1. DNA Topoisomerase 100%
2. Anticarcinogen 100%
3. Acridine 100%
4. Histone Deacetylase Inhibitor 83%
5. DNA Topoisomerase Inhibitor 66%
6. Solid Malignant Neoplasm 66%
7. Histone Deacetylase 66%
8. N (2 Dimethylaminoethyl) 4 Acridinecarboxamide 50%
9. Structure Activity Relationship 50%
10. Vorinostat 50%
11. Hydroxamic Acid 33%
12. Malignant Neoplasm 33%
13. Cytotoxicity 33%
14. Antitumor Activity 16%
15. Side Effect 16%
16. Lead Compound 16%
17. Clinical Trial 16%
18. Camptothecin 16%
19. Hematologic Malignancy 16%
20. Triazole 16%
21. Pharmacokinetics 16%