Evaluation of Platelet-Rich Plasma Combined Nanogel for Angiogenesis and Bone Remodeling Application in Sinus Augmentation Model

Sinus augmentation is a common approach for patients with severe alveolar ridge atrophy. Currently, autogenous bone graft is the most commonly used material for sinus augmentation. Artificial bone substitutes with platelet-rich plasma (PRP) promote early bone formation are development nowadays. To evaluate the effect of platelet-rich plasma (PRP) combined with nanohydrogel on bone remodeling during sinus augmentation in a rabbit model. New Zealand White rabbits are selected and all animals underwent bilateral maxillary sinus augmentation is divided randomly into variant groups based on their time of sacrifice and implanted materials. Both maxillary sinuses received different restoration materials. Each time point, rabbit are examined by computer tomography (CT) and in vivo image system (IVIS) to evaluate its bone remodeling and angiogenesis condition. Histological examinations are also proceeding by optical microscope.