Estimating the Therapeutic Effectiveness of Targeting the Grk6/Nf-Κb/Il-8 Feedback Looping on Triple-Negative Breast Cancer with Chemoresistance and Metastatic / Immunosuppressive Ability( I )

Project: A - Government Institutionb - National Science and Technology Council

Project Details

Description

癌症登計資料顯示,乳癌是台灣婦女癌症的首位,每年逾萬新發乳癌個案、超過2000名婦女死於乳癌, 此現象對國家,人文, 社會, 經濟皆有很大的衝擊,因此提昇乳癌診治品質己是刻不容緩的重要公共衛生議題。這項研究計畫將著重在探討阻斷GRK6/NF-κB /IL-8回饋環線對TNBC化療抗藥性、轉移潛能和免疫抑制能力的影響實驗,獲得的結果將為未來臨床上提供新的治療策略以對抗具化療抗性/轉移/免疫抑制的TNBC。
StatusActive
Effective start/end date8/1/247/31/25

Keywords

  • triple negative breast cancer
  • G protein-coupled receptor kinase 6 (GRK6)
  • NF- κB
  • interleukin-8 (IL-8)
  • immunotherapy