Establish the General Rules of Concomitant Administration of Xiang-Sha-Liu-Jun-Zi-Tang and Its Compatibility with Western Drugs on Cyp Enzymes in Vitro and in Vivo (1/3)

Project: A - Government Institutionb - National Science and Technology Council

Project Details

Description

中藥對於CYP酵素活性各異,處方與西藥如何產生交互作用,本計畫利用香砂六君子湯及相關方劑,拆解其組成,並兩兩配伍,以「體外酵素活性與成分差異」、「體外細胞之CYP酵素活性」及「體內動物實驗與大數據基因表現之臨床評估」三大研究主軸,探討香砂六君子湯中常用藥配伍於CYP酵素之共性規律,作為臨床中藥與抗癌藥物併用之參考,以期達到更安全有效的藥物使用,找出臨床上中藥與抗癌藥併用的規律,提供臨床用藥之參考。
StatusFinished
Effective start/end date8/1/227/31/23

Keywords

  • Xiang-Sha-Liu-Jun-Zi-Tang
  • serum pharmacology
  • CYP3A4
  • CYP2C8
  • Paclitaxel
  • general rules