Effects of Resveratrol Supplementation and Exercise Training on Skeletal Muscle Mass, Muscle Damage, and Exercise Performance-Ⅱ

Due to insufficient exercise training, skeletal mucle loss is beginning form 25 years old. Sarcopenia is the critical reason to effect activities of daily life in seniors. Strength training has been proven to be a great strategy to increase mucle mass and functions. Exercise training provokes skeletal muscle protein synthesis, in the meantime also causes muscle injury, induces muscle protien degradation and muscle cell inflammatory. Net muscle protein balace will become negative in nutrients or rest deficiency. Muscle biogenesis decreasing with aging may induce by signal transmit weakening in muscle protein synthesis pathway. Current studies showed that the phosphatidylinositol 3-kinase /AKT/mammalian target of rapamycin (PI3K/Akt/ mTOR) pathway is an important pathway to regulate skeletal muscle hypertrophy. Therefore, the first year, resveratrol is uesd as a nutriental ergogenic aid which may activate related protein expression of muscle synthesis pathway. In order to understand promotion or protection effects to muscle fibers, we will conduct the intervention of resveratrol and strength training for young and elder mice. In the 2nd year, resveratrol supplementation will be applied sedentary young subjects and strength athletes to understand if it could reduce inflammatory responses and mucle damage degrees as the physical evaluation in recovery. The 3rd year, we will investigate the effect on muscle mass, inflammantary, functional fitness, and reaction time after resveratrol supplementation and resistance training in middle-aged and elderly persons.