Effects of Chronic Intake of High-Lipid/High-Cholesterol Diet and Ketogenic Diet on Bbb, Insulin Metabolism, Cholesterol Homeostasis, and Ad Related Features in Mice

Until 2012, there are more than 190,000 people who are suffering from the dementia. The morbidity is about 8% among those over 65 years old. AD, the most common form of dementia, is also known as the type3DM, which is highly correlated to abnormal regulation of insulin and glucose in the brain. Diets high in fat and cholesterol may have negative effects on health. Hyperlipidemia is considered one of the factors causing insulin resistance. On the other hand, hypercholesterolemia can cause BBB damage and promote the production of A as well as increasing in oxidative stress. Ketone bodies are antioxidative and an alternative source of energy when glucose is no longer an energy source, which is useful under the condition of insulin resistance. In this study, a high-fat/high-cholesterol (HFHC) diet is given to mice for 16 weeks to induce insulin resistance and BBB damage, followed by feeding the mice a ketogenic diet or an HFHC diet with Metformin. We expect to observe that after receiving the ketogenic diet, the cognitive ability and the expression of ADrelated proteins are regulated, in which the mechanism regarding ketogenic diet will be investigated.