Development of Precision Myc/Bcl2/Bcl6 Targeted Therapy on Human B-Cell Lymphoma through Crispr/Cas9 Gene Editing Platform

Project: A - Government Institutionb - National Science and Technology Council

Project Details

Description

我們期望延續近期在nature communication的研究,在DLBCL建立分子動態結合模型分析與動態蛋白質交互作用網路,並以小分子藥物結合位相發展前導藥物或以MYC、BCL2或新穎生物標記為標靶作為臨床治療策略。計畫申請人研究團隊結合生物資料處理、基礎研究與離體組織人體試驗三大主軸,以開發DLBCL有效抗癌策略為目標。
StatusFinished
Effective start/end date8/1/217/31/22

Keywords

  • CRISPR screening library research
  • diffuse large B-cell lymphoma
  • MYC/BCL2 double hits
  • patient-derived cancer/xenograft
  • gene editing
  • biomarker
  • dynamic protein interaction network