Development of Penicillin-Streptomycin to Porous Bioactive Glass Scaffolds (With Li Ions) for Oral and Maxillofacial Restructure Application

With the advent of the super-aged society, establishing adequate social welfare and long-term care systems is of great urgency; in particular, businesses related to the design of medical equipment are extremely crucial for health and economics care. People will need an auxiliary implant to support and recover the structure whether innate or acquired by accident. The application of restructure was used to dentistry, orthopedics, surgical and rehabilitation division widely. Apart from the 3D printed products of prosthesis, the organ transplantation will be another development priority. The role of bioscaffold provides fix and support to the wound in the short term, furthermore, it will lead to the cell growth for a long time after implantation. Bioactive glass (BG) bonding to osteoblasts was published for the first time in 1971. Since then, many kinds of silicon (Si)-based materials have been used in clinical applications. Most studies have attempted to add other elements or oxides groups to enhance the physical properties, mechanical behaviors, and biocompatibility, included the medical drug. Biological scaffolds will help the implant to reconstruct the defect area of the bone, but the strength of the scaffold is also the key point to be considered. In this study, we will add the lithium ions to the bioactive glass scaffold production. Through the X-Ray diffraction (XRD), scanning electron microscopy (SEM), Inductively coupled plasma optical emission spectrometry (ICP-OES) and Brunauer-Emmet-Teller (BET) to evaluate the material characterization. On the other hand, the UV spectrophotometer and cell culture will record the drug release and biocompatibility. It is hoped that the results of this project will be important references for oral and maxillofacial restructure application.