Development of Anti-Cd3 Targeted Immunoadjuvant-Liposome Fused with Dendritic Cells-Derived Exosomes for Colon Cancer Immunotherapy

Project: A - Government Institutionb - National Science and Technology Council

Project Details

Description

癌症仍是人類主要死因之一,以免疫方法治療癌症是目前及未來臨床治療的趨勢,而結合抗體標靶性微脂體可增加免疫細胞胞外泌體於體內專一性活化免疫細胞效率,進一步可增強 T 細胞毒殺癌細胞功效,本計畫將結合微脂體可標靶修飾之特性、胞外泌體帶有生物性免疫活化功能,製成標靶微脂體-胞外泌體新型奈米粒子,進行主動式標靶免疫治療大腸癌。目前多項相關學術研究持續進行,預期未來將可應用於臨床抗癌醫療。
StatusFinished
Effective start/end date8/1/217/31/22

Keywords

  • colon cancer
  • targeted liposome
  • dendritic cell
  • exosome
  • cancer immunotherapy