Development of Antagonistic Bace-2 Antibodies to Improve Type 2 Diabetes by Inducing Pancreatic Beta-Cells Proliferation( I )

Project: A - Government Institution › b - National Science and Technology Council

Project Details

Description

本計畫開發一種可專一性刺激胰島細胞增生之新型anti-BACE-2抗體，逆轉第二型糖尿病末期之胰島凋亡問題；使患者能維持自身胰島細胞調控血糖之功能，減少胰島素補充療法之依賴與低血糖危害。此外，抗體大分子之設計能避免藥物進入腦部及眼睛組織所造成之毒性副作用，大幅提升anti-BACE-2抗體藥物於第二型糖尿病治療之功效及安全性。
StatusFinished
Effective start/end date8/1/21 → 7/31/22

Keywords

  • type 2 diabetes
  • β-site amyloid precursor protein cleaving enzyme 2 (BACE-2)
  • antagonistic anti-BACE-2 antibody
  • islet β cell proliferation
  • avoiding toxic side-effects in brain and eye tissues

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