Development a Lysine Demethylase 5b Mrna and Α-Ketoglutaric Acid Payload Inflammation-Targeted Nanodrug for Promoting Proliferation of Cardiomyocytes Post-Myocardial Infarction

本計畫開發由小分子甲殼素與聚麩胺酸，包覆KDM5B mRNA與酮戊二酸的奈米粒子，在最外層包覆具有靶向發炎細胞的褐藻醣，合成發炎導向KDM5B-LCraF奈米藥物，靶向發炎心肌細胞，以促進心肌梗塞後心肌細胞的增生。