Construction, Expression and Therapeutic Effect of Recombinant Peptides from Toxocara Canis on Opportunistic and Multiple Resistant Staphylococcus Aureus

Project: A - Government Institution › b - National Science and Technology Council

Project Details

Description

抗生素的濫用致伺機性菌與抗藥性菌陡增，危害人類健康或生命甚鉅。金黃色葡萄球菌(Staphylococcus aureus)與多重抗藥性金黃色葡萄球菌(MRSA)是常見的伺機性菌和抗藥性菌。具廣譜性殺菌力的抗微生物胜肽(AMPs)，因天然AMPs (nAMPs)量少，化學合成AMPs (sAMPs)費用昂貴，故藉基因轉殖技術大量取得重組AMPs (rAMPs)為普遍的作法。若本計畫假說與目標得以成功驗證，或可開發更多抗菌的其它腸道寄生蟲源性AMPs，復以基因轉殖技術大量製造無毒性的rAMPs，可以開發作為多重抗藥性菌抗生素的替代臨床用藥，將有助於降低或減緩抗藥性菌株的產生。
StatusFinished
Effective start/end date8/1/21 → 7/31/22

Keywords

  • Antibiotic overuse
  • Staphylococcus aureus
  • multiple resistant Staphylococcus aureus
  • Antimicrobial peptides
  • Caenorhabditis elegans
  • Escherichia coli expression system
  • Toxocara canis recombinant protein
  • Mice
  • Cutaneous damage
  • Sepsis
  • Molecular immunopathology

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