Characterize the Adipokine/Batokine from Perirenal Derived Adipocyte in Enhancing White Adipocyte Differentiation to Brown/Beige Adipocyte for Chronic Nephropathy Disease Study

Project: A - Government Institution › b - National Science and Technology Council

Project Details

Description

糖尿病腎病變是導致末期腎病及透析的主要原因 我們推論腎週脂肪組織所分泌的物質 透過HIF2α、GDF3/10/15或等物質，影響腎臟周圍血管的收縮/舒張 維持腎臟功能和心血管穩定。並進一步利用臨床已開發之用藥缺氧誘導因子脯氨酰羥化酶抑製劑(Roxadusta)來誘發PRAT中白色脂肪分化成棕色脂肪 將作為未來腎臟臨床應用
StatusActive
Effective start/end date8/1/23 → 7/31/26

Keywords

  • perirenal adipose tissue
  • beige adipocyte
  • chronic kidney disease
  • hypoxia-inducible factor

Access Project