Basic and Translational Research of the Active Dna De-Methylation Process by Mammalian Dna Methyltransferases- Physiological Functions and Regulatory Mechanisms

Project: A - Government Institutionb - National Science and Technology Council

Project Details


此計畫在基礎研究方面,將提供全新的,有關DNA去甲基化及表觀遺傳學研究方面的智識,對基因調控,染色體構造,神經可塑性,發育生物學等領域,在學術貢獻上至為重要; 在社會及經濟方面,此計畫的研究成果,特別是對癌症轉移的機制了解及新藥物的研發,亦將影響深遠。
Effective start/end date8/1/227/31/23


  • DNA methyltransferases (DNMTs)
  • Active DNA de-methylation activity of DNMTs
  • Regulation of epithelial-mesenchymal-transition (EMT)
  • Regulation of neuroplasticity
  • Structure-function relationship
  • Co-factors and compound inhibitors of DNA de-methylation by DNMTs