Project Details
Description
此計畫在基礎研究方面,將提供全新的,有關DNA去甲基化及表觀遺傳學研究方面的智識,對基因調控,染色體構造,神經可塑性,發育生物學等領域,在學術貢獻上至為重要; 在社會及經濟方面,此計畫的研究成果,特別是對癌症轉移的機制了解及新藥物的研發,亦將影響深遠。
Status | Finished |
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Effective start/end date | 8/1/22 → 7/31/23 |
Keywords
- DNA methyltransferases (DNMTs)
- Active DNA de-methylation activity of DNMTs
- Regulation of epithelial-mesenchymal-transition (EMT)
- Regulation of neuroplasticity
- Structure-function relationship
- Co-factors and compound inhibitors of DNA de-methylation by DNMTs