Association Study of Persistent Metabolic Syndrome, Inflammatory Markers and Mild Cognitive Decline

Hypertension and diabetes have reported a positive association to the risks of cognitive impairment and dementia. However, dyslipidemia and obesity have studied less and concluded inconsistently. In the 2008-2010 projects, we have recruited 2100 participants from community. Among them, 1533 participants were obtained complete data. The information of basic characteristics from interview and height, weight, waist and hip circumference from physical examinations were collected. The blood samples were collected. We will assess the persistent years, persistent status and components of metabolic syndrome. The cognitive status according by Mini-Mental State Examination (MMSE) and Montreal cognitive assessment (MoCAȑ will be examined and recorded in the 1533 participants the intima median thickness and present of carotid plaque. We aim to report the 5 years cumulative incidence of mild cognitive decline, and to investigate the association between persistent metabolic syndrome and mild cognitive decline. In addition, after adjusted traditional cardiovascular risk factors, the association of cognitive decline will be examined in inflammatory marker-C reactive protein, adeponectine and leptin levels as well as white matter damage.