Association between Markers of Oxidative Stress, Early Left Ventricular Structural and Functional Abnormality in Patient with Severe Mental Illness: Comparisons among Schizophrenia, Bipolar Disorder, and Normal Controls

Project: A - Government Institutionb - National Science and Technology Council

Project Details

Description

學術:期能瞭解重大精神疾病患者(1)在中年以前左心室功能與結構提早變化的程度在兩組不同重大精神疾病之異同; (2)與心臟結構功能改變含LV hypertrophy有關之left ventricular mass index 與relative wall thickness,與心室功能(LVEF)有關之疾病生理、氧化壓力、免疫或藥物有關因素; (3)與心臟衰竭有關之精神藥物之關聯。 社會經濟:將有助於建構更能維護重大精神病患生理健康之醫療模式,由於重大精神病患若併發心臟衰竭將造成醫療成本、社會照護負擔與經濟之損失甚鉅,因此能盡早介入而減此提早心臟老化,有助於促進健康老化之精神醫療長期治療模式。
StatusActive
Effective start/end date8/1/247/31/25

Keywords

  • Severe mental illness
  • schizophrenia
  • bipolar disorder
  • heart failure
  • cardiac ultrasonography
  • oxidative stress
  • cardiac structure and function