Analysis of Ube2c Gene Affecting the Tumor Progression and Metastasis in Prostate Cancer and Its Potential as a Diagnostic Marker and Therapeutic Target

Project: A - Government Institutionb - National Science and Technology Council

Project Details

Description

透過臨床基因數據與攝護腺癌組織染色分析,驗證 UBE2C基因與攝護腺癌病人臨床分期、遠端轉移以及生存呈現關聯性,證明 UBE2C有潛力做為診斷攝護腺癌的標記物。標靶UBE2C的策略可增強臨床化療藥物的敏感度,同時抑制攝護腺癌惡性進展與遠端轉移力,展現標靶UBE2C應用於攝護腺癌治療的廣大優勢。利用RNA-seq技術全面性探討UBE2C影響的轉移性相關基因,提供其它具有應用與藥物開發潛力的標靶基因。最後,開發UBE2C小分子藥物抑制劑,提供臨床上攝護腺癌治療的新策略。
StatusActive
Effective start/end date8/1/237/31/26

Keywords

  • Prostate cancer
  • Metastasis
  • UBE2C
  • Diagnostic marker
  • Drug development

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