Project Details
Description
透過臨床基因數據與攝護腺癌組織染色分析,驗證 UBE2C基因與攝護腺癌病人臨床分期、遠端轉移以及生存呈現關聯性,證明 UBE2C有潛力做為診斷攝護腺癌的標記物。標靶UBE2C的策略可增強臨床化療藥物的敏感度,同時抑制攝護腺癌惡性進展與遠端轉移力,展現標靶UBE2C應用於攝護腺癌治療的廣大優勢。利用RNA-seq技術全面性探討UBE2C影響的轉移性相關基因,提供其它具有應用與藥物開發潛力的標靶基因。最後,開發UBE2C小分子藥物抑制劑,提供臨床上攝護腺癌治療的新策略。
Status | Active |
---|---|
Effective start/end date | 8/1/23 → 7/31/26 |
Keywords
- Prostate cancer
- Metastasis
- UBE2C
- Diagnostic marker
- Drug development
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