Active Targeted Polymer Nanoparticles for Delivery of Structurally Engineered Olaparib-Based Poly (Adp-Ribose) Polymerase (Parp) Inhibitors for Triple-Negative Breast Cancer (Tnbc) Cancer Therapy and Leukemia Cancer Therapy.

1 Objective 1: Through the deployment of the proposed novel delivery system, KNP-17 may be more precisely targeted and released in hypoxic tumor environments, which should enhance its therapeutic effectiveness. The goal of this approach is to reduce off-target effects and improve drug accumulation in triple-negative breast cancer cells. By providing a more effective and targeted treatment option, it may also improve patient outcomes significantly. 2 Objective 2: In this approach, KNP-24 is expected to be more effective at targeting and penetrating leukemic cells in order to improve its therapeutic efficacy. This system is designed to increase drug accumulation in leukaemia cells while minimizing systemic toxicity through the use of GSH-responsive polymer nanoformulations. It could result in more effective treatments and a better prognosis for patients with leukemia. By delivering the drug directly to leukemia cells, this approach differs from traditional leukemia treatments, which often involve systemic chemotherapy that can affect healthy cells. 3 Objective 3. KNP-24 is likely to be released specifically in leukemia tumors' hypoxic regions, thereby improving its therapeutic efficacy. It aims to enhance the drug's effectiveness and minimize its off-target effects by increasing drug absorption in these areas. Thus, it may provide a more precise treatment option, leading to better outcomes for patients. The BHQ3 azo bonds within the copolymers are sensitive to hypoxia, triggering the release of KNP-24 precisely where it is most needed. This specificity allows for increased drug concentration in the hypoxic areas, enhancing therapeutic efficacy while reducing the impact on surrounding healthy tissues. As a result of these 3 novel objectives, we are expected to file 2 patents for the novel way to synthesize the targeted nanoparticles, thereby increasing our chances of commercializing this technology. Our research proposal consists of 3 objectives that will be covered in 3 high-impact journal articles