A Translational Exploration of Antrocin'S Effects for Mitigating Intervertebral Disc Degeneration by Suppressing Nlrp3-Mediated Pyroptosis in Nucleus Pulposus and Myofibroblast Transformation in Annulus Fibrosus

Project: A - Government Institution › b - National Science and Technology Council

Project Details

Description

The successful completion of this study will provide insights into the roles of NLRP3-mediated pyroptosis in intervertebral disc degeneration. Also, we will provide evidence to support antrocin as the lead compound for ameliorating IVDD.
StatusFinished
Effective start/end date8/1/23 → 7/31/24

Keywords

  • Intervertebral disc degeneration (IVDD)
  • annulus fibrosus (AF)
  • nucleus pulposus (NP)
  • NLRP3 inflammasome
  • pyroptosis
  • and antrocin

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