A Preclinical Study on the Repurposing of Dapagliflozin for Treating Metastatic Head and Neck Carcinoma via Disruption of Tumor-Tumor Microenvironment Connection through Tspan1/Slpi Signaling

Project: A - Government Institution › b - National Science and Technology Council

Project Details

Description

We identified TSPAN1 and SLPI as potential targets for HNSCC. Our molecular docking analysis suggested that dapagliflozin could be repurposed for treating HNSCC via targeting TSPAN1 and SLPI.
StatusFinished
Effective start/end date8/1/23 → 7/31/24

Keywords

  • Head and neck squamous carcinoma (HNSCC)
  • tumor microenviron1
  • metastasis
  • M2 tumor-associated macrophages (M2 TAMs)
  • SLGT2 inhibitor
  • drug reposition

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