A Preclinical Study of Glioblastoma Derived Exosomal Btk/Pd-L1/Pd-L2 Signaling in the Regulation of Tumor Immunology and Precision Treatment Implication

Project: A - Government Institutionb - National Science and Technology Council

Project Details

Description

本研究不僅深入探討外泌體內Btk/PD-L1/PD-L2 訊號軸的功能與腫瘤免疫之相關性,而且還提供remibrutinib作為治療惡性膠質母細胞瘤的臨床前證據,這些研究成果將為臨床上創造潛在之腫瘤免疫標誌物,也對於臨床免疫藥物設計上提供方向,增加未來應用於精準腫瘤免疫之實際用途,提升病人存活率。
StatusFinished
Effective start/end date8/1/217/31/22

Keywords

  • Glioblastoma
  • glioblastoma stem cells (GSCs)
  • Btk/PD-L1/PD-L2 oncoimmune signaling
  • remibrutinib
  • exosome
  • hsa-miR-4434
  • Precision onco-immunotherapy