A Novel Igf-1r Car Msc Exosome-Based Drug Delivery System for Sorafenib-Resistant Hccs: Focusing Safety, Efficacy, Bio-Distribution, and Immune-Omics Molecular Mechanism( I )

Project: A - Government Institution › b - National Science and Technology Council

Project Details

Description

本計畫目標為針對醫療未滿足雷沙瓦抗藥性肝癌，研發以IGF-1R受體為靶向之CAR MSC外泌體新穎藥物裝載傳輸策略。我們將以雷沙瓦耐藥性肝癌細胞2D 與3D 類器官(Organoid) 平台進行前臨床細胞 (in vitro)與動物實驗測試 (in vivo)，評估其靶向性外泌體藥物之生物安全性、有效性、組織分布、與免疫體學分子機制。本計畫成果將發展一新穎藥物傳輸之IGF-1R受體靶向CAR MSC外泌體，爲患者提供克服雷莎瓦耐藥性的有效醫療策略。
StatusActive
Effective start/end date8/1/24 → 7/31/27

Keywords

  • Sorafenib-resistant hepatocellular carcinomas
  • Insulin-like growth factor 1 receptor
  • IGF-1R CAR MSC drug-loaded exoxomes
  • Immuno-Omics topology

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