A Nano-Biosensing Method for Ultra-Sensitive and Specific Identification of Potentially Teratogenic Undifferentiated Ipscs in Regenerative Medicine

Project: A - Government Institutionb - National Science and Technology Council

Project Details

Description

Academically, the work can demonstrate how theoretical considerations of electromagnetic field enhancements, adsorption and diffusion kinetics, and polymer theory can be translated into working nanoprobes with uniform signal intensities and enhanced cellular targetability. The technological impact offers a much more sensitive and orthogonal method to current digital PCR methods needed to ensure quality control of PSC products in regenerative medicine. With strong quality control of PSC products, there is also a societal impact. Advancing safe PSC products to clinical translation can address the pressing need for regenerated tissues for the many patients suffering from cardiac diseases. Furthermore, the technique can be applied to other areas of iPSC-based regenerative medicine outside of treating cardiac diseases, such as liver failure and skin wounds.
StatusActive
Effective start/end date8/1/247/31/25

Keywords

  • surface-enhanced Raman scattering
  • regenerative medicin
  • stem cell targeting
  • nano-biosensing
  • pluripotent stem cell products

Fingerprint

Explore the research topics touched on by this project. These labels are generated based on the underlying awards/grants. Together they form a unique fingerprint.