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• Cocaine Induces Sig-1R Nuclear Envelope Localization to Regulate MAOB Expression by Interacting with Emerin-HDACs Co-Repressor Complex

  Chuang, J.

  8/1/14 → 7/31/15

  Project: A - Government Institution › b - Ministry of Science and Technology

• A Series of Studies Analyzing Exercise Behavior and Exploring the Effects of Interventions among Pre-Diabetes, Type 1, and Type 2 Diabetes

  Jeng, C.

  8/1/14 → 7/31/15

  Project: A - Government Institution › b - Ministry of Science and Technology

• Evaluating the Effect of Migration Stimulating Factor on Wound Healing Behavior at the Cellular Level Using Nano-Biomedical Technologies

  Yang, T.

  8/1/14 → 7/31/15

  Project: A - Government Institution › b - Ministry of Science and Technology

• 乳癌是目前世界上女性癌症病患中為數最多的癌症之ㄧ。腺病毒蛋白type 5 E1A (E1A)和許多抗腫瘤作用有關，曾於多種癌症如乳癌、卵巢癌及頭頸癌之病患進行臨床基因治療試驗。許多的研究指出E1A具有多項抗腫瘤的功能，包括抑制腫瘤的發生、增加腫瘤細胞對於化療藥物的感受性以及減少腫瘤轉移的現象。腫瘤的轉移對於癌症患者的死亡率有極大的影響當然也包括了乳癌的患者。E1A於抑制腫瘤發展的過程中具有多重生物學上的意義，這也促使我們想要釐清E1A抑制癌症的機制。因此，我們對於了解E1A抑制癌症轉移相關的分子機制感到有興趣，並期望藉以作為未來改進乳癌病人臨床試驗的基石。我們初步的實驗結果顯示，E1A可以有效的抑制Glucose-regulated protein 78 (GRP78)這種已被廣泛報導和腫瘤惡化及轉移相關的蛋白的表現。 提出此研究計劃之目的在於詳細探討E1A所造成的抑制癌轉移作用中，GRP78所扮演的生物功能及其調控的機轉。為了達到此目的，我們將著重於E1A如何調控GRP78表現並進而展現對乳癌轉移的抑制作用。以下為此項研究計畫的四大主要目標： 目標一：探討GRP78在E1A所抑制之癌細胞移行及侵入作用中所扮演的角色 目標二：研究E1A抑制GRP78表現之分子機轉 目標三：於動物模式中驗證GRP78的表現對於E1A抗腫瘤作用的影響 目標四：探討GRP78及其相關分子的表現在乳癌病人的臨床重要性 完成以上的主要目標能夠幫助我們對於E1A之抗腫瘤轉移作用建立更加詳細的分子訊息傳遞機制。另外，藉由此研究計畫的新發現也許可以對未來發展癌症治療上提供更多具有潛力的標的物。

  Wang, W.

  8/1/14 → 7/31/15

  Project: A - Government Institution › b - Ministry of Science and Technology

• The Influence of Porphyromonas gingivalis Groel in Vascular Cells

  Lin, F.

  8/1/14 → 7/31/15

  Project: A - Government Institution › b - Ministry of Science and Technology

• Efficacy Studies of Tn-Directed Therapeutic Antibody and Immunotoxin in Syngeneic Mouse Tumor Models

  Hwang, J.

  8/1/14 → 7/31/15

  Project: A - Government Institution › b - Ministry of Science and Technology

• Application of Hyaluronic Acid and Resveratrol Modified Carbon Nanotube Scaffolds for Tissue Engineering

  Sheu, S.

  8/1/14 → 7/31/15

  Project: A - Government Institution › b - Ministry of Science and Technology

• Functional Investigation of Heat Shock Protein in Esophageal Squamous Cell Cancer with Implications in Prognostic Prediction and Therapeutic Targeting

  Tzao, C.

  8/1/14 → 7/31/15

  Project: A - Government Institution › b - Ministry of Science and Technology

• Roles of Central OX2R Activities in the Pathophysiology of Hypertension in SHR

  Hwang, L.

  8/1/14 → 7/31/15

  Project: A - Government Institution › b - Ministry of Science and Technology

• Expressing Membrane Antibody Reporter in the Islet Cells of Nonobese Diabetic Mice to Noninvasive Assess the Therapeutic Effects of Drugs or Transgenes for Autoimmune Diabetes

  Chuang, K.

  8/1/14 → 7/31/15

  Project: A - Government Institution › b - Ministry of Science and Technology

• Association between Lipid, Glucose Related Genes and Prognosis of Intra- and Extra-Cranial Stenosis in Stroke Patients

  Chiou, H.

  8/1/14 → 7/31/15

  Project: A - Government Institution › b - Ministry of Science and Technology

• Anti-Aging Effect with the Associated Mechanism by PRP (Platelet-Rich Plasma) in Cartilage---A Fibronectin Fragment Model

  Lee, C.

  8/1/14 → 7/31/15

  Project: A - Government Institution › b - Ministry of Science and Technology

• The Effect of Physical Exercise Program on Pro-Inflammatory and Anti-Inflammatory Cytokines in Patients with Chronic Obstructive Pulmonary Disease

  Ho, S.

  8/1/14 → 7/31/15

  Project: A - Government Institution › b - Ministry of Science and Technology

• The Study of Neurotrophic and Neuroplastic Effects of Exercise and Environmental Enrichment in Mild Traumatic Brain Injury

  Chen, K.

  8/1/14 → 7/31/15

  Project: A - Government Institution › b - Ministry of Science and Technology

• https://www.grb.gov.tw/search/planDetail?id=8356932&docId=447412

  Lin, C.

  8/1/14 → 7/31/15

  Project: A - Government Institution › b - Ministry of Science and Technology

• Chemo-Sensitizer Conjugated Carbon Nanotubes as a Novel Cancer Therapeutical Delivery System

  Cho, E.

  8/1/14 → 7/31/15

  Project: A - Government Institution › b - Ministry of Science and Technology

• The Effect of Economic Recession on Health and Health Care Service Utilization of Elderly: Comparisons among Welfare State Regimes

  Chuang, K.

  8/1/14 → 7/31/15

  Project: A - Government Institution › b - Ministry of Science and Technology

• An Investigation of the Effects of Tea Component on the Inhibition of Leukocyte Nicotinic Acetylcholine Receptor Expression on Breast Cancer Patients

  Tu, S.

  8/1/14 → 7/31/15

  Project: A - Government Institution › b - Ministry of Science and Technology

• Roles of Toll-Like Receptor-4 and Hif-1 in Propofol-Involved Protection against Traumatic Brain Injury-Induced Dysfunction of the Blood-Brain Barrier

  Chen, R.

  8/1/14 → 7/31/15

  Project: A - Government Institution › b - Ministry of Science and Technology

• To Investigate the Role of SPNS2 in Determining Individual Susceptibility to Hypoxic Challenge

  Yang, C. H.

  8/1/14 → 7/31/15

  Project: A - Government Institution › b - Ministry of Science and Technology

• Investigation on Dental Implant Stability Detection Using Damping Factor as a Parameter

  Huang, H.

  8/1/14 → 7/31/15

  Project: A - Government Institution › b - Ministry of Science and Technology

• Arsenic Methylation Capacity, Methylenetetrahydrofolate Reductase and Dna Methylation Gene Polymorphisms, Plasma Selenium Concentration and Selenoprotein Gene Polymorphisms and Renal Cell Carcinoma

  Hsueh, Y.

  8/1/14 → 7/31/15

  Project: A - Government Institution › b - Ministry of Science and Technology

• Therapeutic Implications of Down-Regulation of Microglia Activation Following Repetitive Traumatic Brain Injury-Induced Chronic Traumatic Encephalopathy

  Chang, C.

  8/1/14 → 7/31/15

  Project: A - Government Institution › b - Ministry of Science and Technology

• Association between Human Endogenous Retrovirus and Cancers Using RNA-Seq Data

  Lee, Y. G.

  8/1/14 → 7/31/15

  Project: A - Government Institution › b - Ministry of Science and Technology

• Explore the Molecular Mechanisms and Application of microRNA-16 in In Acute Kidney Injury

  Chen, H.

  8/1/14 → 7/31/15

  Project: A - Government Institution › b - Ministry of Science and Technology

• 異甘草素對人類子宮內膜癌及卵巢癌細胞增生及轉移之影響效應

  Hsia, S.

  6/1/14 → 7/31/15

  Project: C - Project of Alliance › p - Taipei Medical University Hospital

• The Roles of Novel CCCH Zinc Finger Genes on the Regulation of Cell Proliferation and Inflammation

  Liang, Y.

  8/1/14 → 7/31/15

  Project: A - Government Institution › b - Ministry of Science and Technology

• Role of Synovium in Osteoarthritis Progress and Cartilage Regeneration

  Yang, K.

  8/1/14 → 7/31/15

  Project: A - Government Institution › b - Ministry of Science and Technology

• Pre- and Post-Operative Life Experience, Quality of Life and Physical Activity among Patients with Total Kneeand Hip Replacement

  Lin, P.

  8/1/14 → 7/31/15

  Project: A - Government Institution › b - Ministry of Science and Technology

• Application of Clinical Anti-Arthralgia Formulas of Traditional Chinese Medicine to Arthritis

  Wang, C.

  8/1/14 → 7/31/15

  Project: A - Government Institution › b - Ministry of Science and Technology

• Effects of Resveratol on Proliferation of Leiomyoma: in Vitro and in Vivo Study (A09)

  Hsia, S.

  8/1/14 → 7/31/15

  Project: A - Government Institution › b - Ministry of Science and Technology

• Evaluate the Molecluar Mechanims and Clinical Application on Atf3 Regulated microRNAs

  Lin, H.

  8/1/14 → 7/31/15

  Project: A - Government Institution › b - Ministry of Science and Technology

• Development of Novel Therapeutic Agents for Herceptin Resistance Breast Cancer Cells through Targeting Nicotinic Acetylcholine Receptors

  Lee, C.

  8/1/14 → 7/31/15

  Project: A - Government Institution › b - Ministry of Science and Technology

• Study of Postoperative Adverse Outcomes of Surgical Patients Using Taiwan National Health Insurance Database

  Chen, T.

  8/1/14 → 7/31/15

  Project: A - Government Institution › b - Ministry of Science and Technology

• The Study of Antidepressive and Cognition Improvement Property of N-3 Fatty Acids on Metabolic Syndroms

  Huang, S.

  8/1/14 → 7/31/15

  Project: A - Government Institution › b - Ministry of Science and Technology

• An Association Study of Early Arsenic Exposure and Genes Related to Arsenic Metabolic Capacity on the Risk of Cardiovascular Disease (I)

  Hsieh, F.

  8/1/14 → 7/31/15

  Project: A - Government Institution › b - Ministry of Science and Technology

• Modifying the Impact of Maternal Psychopathology on Adverse Infant Health Outcomes---Effects of Paternal Involvement and a Trial on Positive Activity Intervention

  Chen, Y.

  8/1/14 → 7/31/15

  Project: A - Government Institution › b - Ministry of Science and Technology

• Role of miR-21 in Regulating TET I-Hydroxymethylcytosine and Chemotherapeutic Response in Colorectal Cancer (I)

  Yang, P.

  8/1/14 → 7/31/15

  Project: A - Government Institution › b - Ministry of Science and Technology

• MicroRNA-184在肺腫瘤化和臨床預後之角色

  Lee, H.

  8/1/14 → 7/31/15

  Project: C - Project of Alliance › r - Tung's Taichung MetroHarbor Hospital

• Study of Nano-Size Memberane Tube for Tendon to Bone in Anterior Cruciate Ligament Reconstruction

  Chen, C.

  8/1/14 → 7/31/15

  Project: A - Government Institution › b - Ministry of Science and Technology

• Evaluation on Cervical Cancer Prevention and Treatment Policy in Taiwan

  Tang, C.

  8/1/14 → 7/31/15

  Project: A - Government Institution › b - Ministry of Science and Technology

• The Effect of Long Acting GnRH Agonist Treatment on Mitochondrial Function in

  Tzeng, C.

  8/1/14 → 7/31/15

  Project: A - Government Institution › b - Ministry of Science and Technology

• 開發微米中空纖維陣列膜作為血液過濾器之研究

  Chen, C.

  6/1/14 → 7/31/15

  Project: C - Project of Alliance › p - Taipei Medical University Hospital

• Using Cometing Risk Model for Death and Multi-State Stochastic Process for the Behaviour of Betel-Quid Chewing and Smoking to Estimate the Potential Years of Life Lost Due to Betel Quid and to Estiamte the Impact of Qutiing Betel-Quid Chewing

  Yen, M.

  8/1/14 → 7/31/15

  Project: A - Government Institution › b - Ministry of Science and Technology

• An Association Study of Mitochondrial Function Related Genes and Ischemic Stroke

  Hsieh, F.

  8/1/14 → 7/31/15

  Project: A - Government Institution › b - Ministry of Science and Technology

• TMU102-AE1-B15

  Wu, C.

  1/1/14 → 7/31/15

  Project: B - Project of TMU › i - Other (Funded by TMU)

• Establish the Research Platform for Studying Triple-Negative Breast Tumor Microenvironment Regulation: the Hyaluronan Synthase-3 Mediated Antitumor Effects as an Example.

  Ho, Y. & Wu, C.

  8/1/14 → 7/31/15

  Project: A - Government Institution › b - Ministry of Science and Technology

• The Role of Wnt5a and Hsp90 in the Wnt/Beta-Catenin Signaling Pathway of Colorectal Cancer (I)

  Lee, K.

  8/1/14 → 7/31/15

  Project: A - Government Institution › b - Ministry of Science and Technology

• Functional Role of Transcription Factor Sp1 in Brain Neuronal Injury (III)

  Chang, W.

  8/1/14 → 7/31/15

  Project: A - Government Institution › b - Ministry of Science and Technology

• Genetic Polymorphisms in microRNA and Risk of the Post-Thrombolytic Hyperglycemia in Acute Ischemic Stroke and Its Prognosis Study

  Hsieh, Y.

  8/1/14 → 7/31/15

  Project: A - Government Institution › b - Ministry of Science and Technology