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• b - Ministry of Science and Technology

  Calcitriol Modulates Cardiac Fibroblasts through Noncanonical Pathway of Receptor for Advanced Glycation End Products and Fibroblast Growth Factor Receptor Signaling: Implicated in Cardiac Fibrosis in Diabetes

  Lee, T.

  8/1/19 → 7/31/20

  Project: A - Government Institution › b - Ministry of Science and Technology

• Effects of Onion and Allium Vegetables Cultivated in Taiwan and Mongolia on Osteoporosis

  Chen, Y.

  8/1/15 → 7/31/16

  Project: A - Government Institution › b - Ministry of Science and Technology

• 醫病共享決策用於高齡心血管病患之治療選擇初探：病患與醫師觀點

  Hsu, Y.

  7/1/21 → 2/28/22

  Project: A - Government Institution › b - Ministry of Science and Technology

• miR-103/107在大腸癌幹性中所扮演的角色探討

  Chen, H.

  4/1/16 → 9/30/17

  Project: A - Government Institution › b - Ministry of Science and Technology

• 建構虛擬斑馬魚系統以研析化合物毒性(1/3)

  Tung, C.

  8/1/21 → 7/31/22

  Project: A - Government Institution › b - Ministry of Science and Technology

• Bsp-Like Repeat Family Proteins in Bacterial Immune Evasion and Biofilm Formation in Viridans Streptococci-Induced Infective Endocarditis

  Jung, C.

  8/1/19 → 7/31/20

  Project: A - Government Institution › b - Ministry of Science and Technology

• 常用中藥與抗生素之交互作用評估

  Lee, C.

  7/1/18 → 2/28/19

  Project: A - Government Institution › b - Ministry of Science and Technology

• 合成劇噻吩石墨烯智慧型基材以建立仿神經元微環境來探討癌症引發之周邊神經侵犯研究

  Huang, W.

  7/1/18 → 2/28/19

  Project: A - Government Institution › b - Ministry of Science and Technology

• Inhibition of IkB Degradation Reduces Collagen Production via Downregulation of Androgen Receptor Expression in Dihydropyridine-Induced Gingival Overgrowth Cells

  Lu, H.

  8/1/15 → 7/31/16

  Project: A - Government Institution › b - Ministry of Science and Technology

• 繪本教學介入對學齡期自閉症兒童人際互動之成效探討

  Kuo, S.

  7/1/20 → 2/1/21

  Project: A - Government Institution › b - Ministry of Science and Technology

• The Logic of Care in Miscarriage and ‘An-Tai’ in Taiwan: Adaptive Practice and Accountability from Medical Professionals, Women and Their Partners (1/2)

  Shih, L.

  8/1/22 → 7/31/23

  Project: A - Government Institution › b - Ministry of Science and Technology

• 建立新興環境汙染物與藥物毒理預測平台之研究

  Hsu, K.

  7/1/20 → 2/1/21

  Project: A - Government Institution › b - Ministry of Science and Technology

• Effect of a Leader Empowering Behaviors Intervention on Staff Nurse and Resident Well-Being in Long-Term Care Settings—Part Ii

  Chen, I.

  8/1/17 → 7/31/18

  Project: A - Government Institution › b - Ministry of Science and Technology

• 酸性環境鐵劑吸收之療效評估

  Chen, S. H.

  7/1/19 → 2/1/20

  Project: A - Government Institution › b - Ministry of Science and Technology

• Research on Development of Clound Computing Platform for Decision Support Systems Healthcare by Healthcare Big Data and Analytics

  Chiang, I.

  8/1/14 → 7/31/15

  Project: A - Government Institution › b - Ministry of Science and Technology

• Modulation of Tumor Microenvironment by Nucleic Acid Chimeras as a New Paradigm for Adjuvant Cancer Therapy

  Yeh, S.

  1/1/12 → 7/31/12

  Project: A - Government Institution › b - Ministry of Science and Technology

• Factors Related to Infant Feeding Practice and Weight Change in Postpartum Women

  Chen, Y. C.

  8/1/10 → 7/31/11

  Project: A - Government Institution › b - Ministry of Science and Technology

• Development of Penicillin-Streptomycin to Porous Bioactive Glass Scaffolds (With Li Ions) for Oral and Maxillofacial Restructure Application

  Fan, F.

  8/1/18 → 10/1/19

  Project: A - Government Institution › b - Ministry of Science and Technology

• 利用機器學習模型預測耐甲氧西林金黃色葡萄球菌血流感染病人使用萬古黴素和太古盤寧素之腎毒性風險

  Chen, S. H.

  7/1/21 → 2/28/22

  Project: A - Government Institution › b - Ministry of Science and Technology

• 標題：謹慎設計抗胃癌藥物：結構簡化方法、骨架躍遷策略以及對二氧化矽負載的質子酸/路易斯酸催化的多組分反應以產生關鍵中間體的詳盡探索

  Nepali, K.

  8/1/21 → 7/31/22

  Project: A - Government Institution › b - Ministry of Science and Technology

• To Investigate the Advantages of Paired Associative Nerve Stimulation on Motor Function and Cortical Excitability in Individuals with Incomplete Spinal Cord Injury (Ii)

  Lai, C.

  8/1/22 → 7/31/23

  Project: A - Government Institution › b - Ministry of Science and Technology

• 帶殼台灣藜之乙醇萃取物對小鼠DSS誘導慢性腸炎之預防效果

  Shih, C.

  7/1/21 → 2/28/22

  Project: A - Government Institution › b - Ministry of Science and Technology

• 強化體育技能精熟學習之適性化跨平台多媒體學習歷程系統：以羽球動作技能為 例(2/2)

  Hung, H.

  5/1/18 → 4/30/19

  Project: A - Government Institution › b - Ministry of Science and Technology

• 「虛擬實境輔助解剖教學」對於超音波影像中週邊神經軌跡追蹤能力的成效評估: 疫情下對於超音波導引區域麻醉教學的因應與創新

  Lin, J. A.

  8/1/21 → 7/31/22

  Project: A - Government Institution › b - Ministry of Science and Technology

• Investigation of the Effects of Ccl5 Mediated Neuronal Energy Metabolism on Hippocampal Neurogenesis and Memory Formation under Normal and Alzehemier’S Disease Conditions

  Chou, S.

  8/1/22 → 7/31/23

  Project: A - Government Institution › b - Ministry of Science and Technology

• 建立內皮系細胞血管新生篩選平台以識別中心新生血管促進及拮抗因子

  Hwang, W.

  7/1/17 → 2/28/18

  Project: A - Government Institution › b - Ministry of Science and Technology

• 串疊結構鈣鈦礦太陽能電池之關鍵技術開發

  Chang, C.

  8/1/17 → 9/21/18

  Project: A - Government Institution › b - Ministry of Science and Technology

• Journey of Professional Identity Building of Young Physicians-- Examining the Impact of Gender, Stress, Duty Hours, and Work Loading.

  Chiu, C.

  8/1/19 → 7/31/20

  Project: A - Government Institution › b - Ministry of Science and Technology

• 預凝膠法合成之酸鹼應答型之磷酸鈣/海藻膠奈米藥物載體應用於膀胱癌的治療

  Liu, C.

  8/1/21 → 7/31/22

  Project: A - Government Institution › b - Ministry of Science and Technology

• Investigation of Host Factors Affecting the Pathogenesis of Enterovirus 71 in Neuron and Non-Returnable Cells

  Lin, J.

  12/1/14 → 11/30/15

  Project: A - Government Institution › b - Ministry of Science and Technology

• The Study of Content of Identity and Identification--The Interplay of Individual and Organizational Level

  Chiu, C.

  8/1/16 → 7/31/17

  Project: A - Government Institution › b - Ministry of Science and Technology

• Dissected the Role of Thrombomodulin in the Clinical Diagnostic and Therapeutic Impacts for Breast Cancer and the Regulation Mechanisms

  Hung, C.

  8/1/17 → 7/31/18

  Project: A - Government Institution › b - Ministry of Science and Technology

• 嚴重氣喘患者呼吸道上皮細胞之IgE媒介警告素生成過程，其High affinity IgE receptor及E-cadherin之角色與機轉(2/2)

  Weng, C.

  10/1/20 → 9/1/21

  Project: A - Government Institution › b - Ministry of Science and Technology

• 利用基因網絡分析尋找假定蛋白質 （hypothetical protein)與抗藥性的關係

  Wu, Y.

  7/1/18 → 2/28/19

  Project: A - Government Institution › b - Ministry of Science and Technology

• The Promise of Prenatal Genetic Screening and Testing: Noninvasive Prenatal Diagnosis in Taiwan

  Shih, L.

  8/1/18 → 7/1/19

  Project: A - Government Institution › b - Ministry of Science and Technology

• 研發選擇性非異羥肟酸組蛋白去乙醯酶 4抑制劑

  Hsu, K.

  7/1/18 → 2/28/19

  Project: A - Government Institution › b - Ministry of Science and Technology

• Research and Development of Multi-Purpose Microtube Array (Mta) Membrane: Applications Identification through Materials Selection and Development of Prototype Production Unit via Fabrication Process Optimization

  Chen, C.

  8/1/12 → 7/31/13

  Project: A - Government Institution › b - Ministry of Science and Technology

• The Effect of Blood Sugar Regulation and Molecular Mechanism by White Potato Extract

  Li, S.

  8/1/12 → 7/31/13

  Project: A - Government Institution › b - Ministry of Science and Technology

• Technology & Distrust: a Study on Biomed Research & Development Models and Legal Framework( I )

  Chia, W.

  2/1/20 → 1/31/21

  Project: A - Government Institution › b - Ministry of Science and Technology

• 管理階層政商關係對生物科技公司首次公開募股後辦理首次現金增資期程之影響

  Hsiao, Y.

  7/1/20 → 2/1/21

  Project: A - Government Institution › b - Ministry of Science and Technology

• 大腸直腸癌已躍居世界上癌症死亡率第二名，屬於固體型腫瘤，缺氧常見於此類 腫瘤，並誘發HIF-1α 表現而導致抗藥性及預後較差，因此抑制HIF-1α 被視為新的抗 癌策略。Zebularine (Zeb)是較穩定之DNA methyltransferase (DNMT)抑制劑，可殺死癌 細胞而不影響正常細胞，對小鼠也不具毒性。我們初步結果顯示，Zeb 可抑制人類大 腸癌細胞株HCT116 之HIF-1α表現，代表Zeb 是治療大腸直腸癌之潛力藥物。我們的 初步也證明Zeb對HCT116具毒殺性，對小鼠大腸癌也有療效。細胞自我吞噬(autophagy) 是指細胞在惡劣環境下，經由吞噬細胞內物質產生能量渡過外界壓力的一種保護機 制；也有研究報導指出，藥物會誘導癌細胞產生autophagy，造成細胞過度吞噬其內容 物而死亡，因此，autophagy在癌細胞為保護或是引發毒殺作用，目前仍無定論。缺氧 也會透過HIF-1α 導致autophagy 而促進細胞存活，但嚴重缺氧或無氧狀態則可透過活 化AMPK及unfolded protein response (UPR)造成autophagic cell death。我們初步結果顯 示，除抑制HIF-1α 表現外，Zeb 也可活化AMPK、UPR/ER stress、以及autophagy， 因此我們推測Zeb 可在缺氧狀態下，促進autophagic cell death。3 年內我們將執行4 項 目標： (1) 探討Zeb 在各種癌細胞及活體模式之抗癌作用。（第一年） (2) 研究Zeb 抑制HIF-1α表現之分子機轉。（第一年到第二年） (3) 研究Zeb 誘發autophagy之分子機轉。（第二年到第三年） (4) 探討Zeb 對缺氧導致抗藥性之作用。（第三年）

  Yang, P.

  8/1/13 → 7/31/14

  Project: A - Government Institution › b - Ministry of Science and Technology

• Dysmetabolic Iron Overload Syndrome and Testosterone Biosynthesis: Role of Fat and Iron Enriched Diet

  Chang, J.

  8/1/18 → 7/1/19

  Project: A - Government Institution › b - Ministry of Science and Technology

• Avoidable Hospitalizations and Primary Care Manpower in a Universal Health Insurance System: a 15-Year Trend Analysis

  Huang, K.

  8/1/11 → 7/31/12

  Project: A - Government Institution › b - Ministry of Science and Technology

• A Study on the Evaluation of Stromal Stem Cells and Stromal Fibroblasts in Human Tissue Regenerative and Cancer Forming Potentials

  Shih, T.

  8/1/12 → 7/31/13

  Project: A - Government Institution › b - Ministry of Science and Technology

• Taiwanese Women’S Situatedness of Being Either Single, Childless or Pregnant in Advanced Maternal Age

  Shih, L.

  8/1/20 → 7/1/21

  Project: A - Government Institution › b - Ministry of Science and Technology

• 活性維生素D經由非典型高等糖化終產物受體與纖維母細胞生長因子受體訊息調控心臟纖維母細胞與糖尿病心臟纖維化之關聯(3/3)

  Lee, T.

  8/1/20 → 7/1/21

  Project: A - Government Institution › b - Ministry of Science and Technology

• 高性能半透明鈣鈦礦太陽能電池之整合性研究

  Chang, C.

  8/1/17 → 9/21/18

  Project: A - Government Institution › b - Ministry of Science and Technology

• Developing New Diagnostic and Therapeutic Strategies for Lung Cancer with ROS1, RET and NTRK1 Mutations in Patients without EGFR, KRAS and ALK Mutations

  Liu, H.

  8/1/14 → 7/31/15

  Project: A - Government Institution › b - Ministry of Science and Technology

• Investigation on the Epigenetic Regulation of Autophagy

  Yang, P.

  8/1/14 → 7/31/15

  Project: A - Government Institution › b - Ministry of Science and Technology

• 疫苗研發與應用之倫理、法律、社會影響整合型研究計畫－子計畫三-全新與未充分驗證疫苗導入之公共政策與社會認知(1/2)

  Tsai, F.

  1/1/14 → 12/31/14

  Project: A - Government Institution › b - Ministry of Science and Technology